中华临床医师杂志(电子版) 2017年2月,11卷3期

临床论著

早期新生儿与足月新生儿胼胝体长度的比较研究

尹笑笑1 孙红光1 戚庭月1 韩欣宁2 吴明赴3 孟国萍1

225100 江苏省,扬州市第一人民医院超声科1,妇产科2,新生儿科
孙红光,Email: yzshg@126.com

摘要:  目的 比较早期新生儿与足月新生儿胼胝体长度(CC-L),探讨CC-L在新生儿大脑发育评价中的临床应用价值。方法 随机选取本院孕37~40+6周出生的单胎新生儿97例,平均孕周(39.29±1.14)周,平均体质量(3 374±412)g。按孕周分为早期新生儿组(孕37~38+6周出生)及足月新生儿组(孕39~40+6周出生)。所有新生儿于出生后24 h内进行颅脑超声检查,测量并比较两组CC-L是否具有统计学差异,统计并分析性别和体质量与CC-L的关系。结果 足月新生儿的平均孕周、体质量、CC-L分别为(39.98±0.67)周、(3 495±365)g、(44.89±2.27)mm;早期新生儿的平均孕周、体质量、CC-L分别为(38.20±0.67)周、(3 170±406)g、(43.68±1.33)mm,足月新生儿体质量、CC-L均高于早期新生儿组,差异具有统计学意义(P<0.05)。新生儿的CC-L与体质量、性别均无明显相关性。结论 足月新生儿比早期新生儿CC-L更长,大脑发育更好,在孕37周以上出生的正常新生儿中,体质量并不是大脑发育的重要因素。

关键词:胼胝体长度; 早期新生儿; 足月新生儿; 大脑发育

江苏省科技厅临床医学科技专项(BL2014064);扬州市自然科学基金青年科技人才项目(YZ2014049)

Comparative study on the length of corpus callosum in early-term neonates and full-term neonates 

in Xiaoxiao1, Sun Hongguang1, Qi Tingyue1, Han Xinning2, Wu Mingfu3, Meng Guoping1

1Department of Ultrasound, 2Department of Gynaecology and Obstetrics, 3Department of Neonatal, Yangzhou No.1 People's Hospital, Yangzhou 225100, China
Sun Hongguang, Email: yzshg@126.com

Abstract:  Objective To compare the corpus callosum length (CC-L) in early-term neonates and full-term neonates, and to discuss the value of these parameters in evaluation of neonatal brain development. Methods Ninety-seven neonates, born between 37-40+6 weeks, were enrolled in this prospective study. The mean gestational age and the mean weight were (3 374±412) g and (39.29±1.14) weeks. 44 cases in early-term neonates (born between 37-38+6 weeks) and 53 cases in full-term neonates (born between 39-40+6 weeks). All neonates did cranial ultrasound examination in 24 hours after birth, CC-L were measured and compared between the two groups, analyzed the relationship between gender, body weight and CC-L. Results The mean gestational week, mean weight and mean CC-L of early-term neonates were (39.98±0.67) weeks, (3 495±365) g, (44.89±2.27) mm, the mean gestational week, mean weight, mean CC-L of full-term neonates were (38.20±0.67) weeks, (3 170±406) g and (43.68±1.33) mm, the mean weight, mean CC-L of full-term neonates were higher than early-term neonates (P<0.05). CC-L were not significantly correlated with body weight, gender. Conclusions CC-L of full-term neonates is longer than early-term neonates. Suggested that full-term neonates brain development was better than early-term neonates. In full-term and early-term neonates, weight is not the important factor in brain development.

Keywords:Corpus callosum length; Early-term neonates; Full-term neonates; Brain development

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参考文献

  [1] Anderson NG, Laurent I, Cook N, et al. Growth rate of corpus callosum in very premature infants[J]. AJNR Am J Neuroradiol, 2005, 26(10): 2685-2690.

  [2] Anderson NG, Laurent I, Woodward LJ, et al. Detection of impaired growth of the corpus callosum in premature infants[J]. Pediatrics, 2006, 118(3): 951-960.

  [3] Thompson DK, Inder TE, Faggian N, et al. Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes[J]. Neuroimage, 2012, 59(4): 3571-3581.

  [4] ACOG Committee Opinion No 579: Definition of term pregnancy[J]. Obstet Gynecol, 2013, 122(5): 1139-1140.

  [5] 刘芳, 曹士考, 刘皎然, 等. 新生儿胼胝体长度与孕周、出生体重的相关性研究[J]. 临床军医杂志, 2009, 37(3): 391-392, 395.

  [6] Pashaj S, Merz E, Wellek S. Biometry of the fetal corpus callosum by three-dimensional ultrasound[J]. Ultrasound Obstet Gynecol, 2013, 42(6): 691-698.

  [7] 徐晚虹, 金鹏, 李少辉, 等. 二维超声测量20~40周正常胎儿胼胝体径线[J]. 福建医科大学学报, 2008, 42(3): 280-283.

  [8] 胡原, 陈文娟, 张号绒, 等. 早产儿胼胝体发育的超声监测[J]. 医学影像学杂志, 2010, 20(7): 1038-1041.

  [9] 刘芳, 刘皎然, 杜志方, 等. 早产儿胼胝体生长率与运动发育迟滞关系的研究[J]. 中国当代儿科杂志, 2008, 10(6): 701-704.

  [10] Narberhaus A, Segarra D, Caldu X, et al. Gestational age at preterm birth in relation to corpus callosum and general cognitive outcome in adolescents[J]. J Child Neurol, 2007, 22(6): 761-765.

  [11] Davis EP, Buss C, Muftuler LT, et al. Children's Brain Development Benefits from Longer Gestation[J]. Front Psychol, 2011, 2: 1.

  [12] Davis EP, Sandman CA. The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development[J]. Child Dev, 2010, 81(1): 131-148.

  [13] Rose O, Blanco E, Martinez SM, et al. Developmental scores at 1 year with increasing gestational age, 37-41 weeks[J]. Pediatrics, 2013, 131(5): e1475-1481.

  [14] 赵枫, 雷莉. 巨大儿发生的相关因素及生长发育情况分析[J]. 中国基层医药, 2011, 18(23): 3194-3196.

  [15] 李光辉, 孔丽君, 李智文, 等. 2011年全国多中心单胎足月巨大儿发生情况调查及危险因素分析[J]. 中华围产医学杂志, 2013, 16(9): 546-550.

  [16] Achiron R, Lipitz S, Achiron A. Sex-related differences in the development of the human fetal corpus callosum: in utero ultrasonographic study[J]. Prenat Diagn, 2001, 21(2): 116-120.

  [17] Liu F, Cao S, Liu J, et al. Ultrasound measurement of the corpus callosum and neural development of premature infants[J]. Neural Regen Res, 2013, 8(26): 2432-2440.

(编辑:戚红丹 收稿日期:2016-09-21)