中华临床医师杂志(电子版) 2017年2月,11卷3期

临床论著

抑郁症患者负性生活事件与焦虑症状的关系: 神经质的调节作用

杨艳慧1,2 李素萍1 杜巧荣1 曹晓华1 孙宁1 张克让1,2

国家自然科学基金面上项目(81171290,81471379)
张克让,Email: atomsxmu@vip.163.com

摘要:  目的 探讨抑郁症患者的神经质水平在负性生活事件与焦虑症状之间的调节作用。方法 采用生活事件量表、汉密尔顿抑郁量表、汉密尔顿焦虑量表、艾森克人格问卷对252例抑郁症患者进行评估。运用皮尔逊相关分析、层级回归分析等方法分析神经质的调节作用。结果 回归模型表明,抑郁症患者的焦虑症状预测了抑郁的严重程度(B=0.71,t=16.08,P<0.001)。神经质(B=0.39,t=6.61,P<0.001)与负性生活事件(B=0.25,t=4.04,P<0.001)对焦虑症状有显著的预测作用,负性生活事件和神经质的交互作用有统计学意义(B=1.12,t=2.08,P=0.038)。结论 抑郁症患者的焦虑症状加重了抑郁的严重程度;神经质负性生活事件和焦虑症状之间起调节作用,高神经质的抑郁症患者在遭遇负性生活事件时更易表现出焦虑症状。

关键词:抑郁; 神经质; 负性生活事件; 焦虑; 调节作用

国家自然科学基金面上项目(81171290,81471379)

Moderating effect of neuroticism on relationship between negative life events and anxiety symptoms in depression

Yang Yanhui1,2, Li Suping1, Du Qiaorong1, Cao Xiaohua1, Sun Ning1, Zhang Kerang1,2.

1Department of Psychiatry, the First Hospital of Shanxi Medical University, Taiyuan 030001, China; 2Shanxi Medical University, Taiyuan 030001, China
1Department of Psychiatry, the First Hospital of Shanxi Medical University, Taiyuan 030001, China; 2Shanxi Medical University, Taiyuan 030001, China

Abstract:  Objective To examine whether neuroticism moderate the relationship between negative life events and anxiety symptoms in depression. Methods 252 depression completed the Life Event Scale, Hamilton Depression Scale-17, Hamilton Anxiety Scale and Eysenck Personality Questionnaire. Pearson correlation analysis and hierarchical regression analysis were used to analyze the moderation of neuroticism. Results Anxiety showed significant effects on depression (B=0.71, t=16.08, P<0.001). Neuroticism (B=0.39, t=6.61, P<0.001) and negative life events (B=0.25, t=4.04, P<0.001) showed significant effects on anxiety. Neuroticism and negative life events had a interact effect on anxiety (B=1.12, t=2.08, P=0.038). Conclusions Anxiety increased the severity of depression. Neuroticism can moderate the relationship between negative life events and anxiety in depression, depression with higher level of neuroticism are at greater risk to develop anxiety disorders when encountering negative life events.

Keywords:Depression; Neuroticism; Negative life events; Anxiety; Moderator effect

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(编辑:戚红丹 收稿日期:2016-12-14)