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消化系统肿瘤FDG PET/CT显像标准摄取值与分子生物学的相关性
欧阳林，周丽娟，时昭胤，杨赞军，刘威宏，寿元苗欧阳林、周丽娟、时昭胤、杨赞军、刘威宏、寿元苗，福建漳州 解放军第175医院(厦门大学附属东南医院)影像科，363000
摘 要:目的 探讨消化系统肿瘤PET/CT显像FDG标准摄取值(SUV)与其分子生物学行为的相关性。方法 回顾性分析资料完整的24例消化系统肿瘤患者PET/CT、手术和病理资料，分析患者PET/CT显像FDG摄取指数SUV值与癌肿浸润深度、转移状况之间的相关性以及与肿瘤增殖因子Ki-67、癌基因p53、癌基因C-erbB-2表达的相关性。结果 24例消化系统肿瘤患者SUV值最低为2.5，最高为12，平均值6.34±2.54，按SUV值高低将患者病变均分为低代谢和高代谢两组，低代谢组SUV均值4.39±1.31，高代谢组SUV均值8.48±1.38，两组间SUV值均数差异有统计学意义(t＝2.418，P＜0.05)，两组间病变浸润深度差异无统计学意义(χ2＝0，P＞0.05)，两组间病变邻近淋巴结转移发生率无统计学意义(χ2＝0.686，P＞0.05)。24例患者病变Ki-67值最低为20%，最高为65%，平均值(41±11)%。SUV值与Ki-67值相关性无统计学意义(r＝－0.22，P＞0.05)。低代谢组和高代谢组Ki-67值分别为(43±13)%和(38±9)%，组间差异无统计学意义(t＝0.225，P＞0.05)。低代谢组和高代谢组p53阳性表达例数差异无统计学意义(χ2＝0.711，P＞0.05)。低代谢组和高代谢组C-erbB-2阳性表达例数差异无统计学意义(χ2＝0.686，P＞0.05)。结论 消化系统肿瘤PET/CT显像FDG摄取指数SUV值变异较大，与癌肿浸润深度和邻近淋巴结有无转移之间没有相关性，与肿瘤增殖因子Ki-67、癌基因p53及C-erbB-2表达程度无显著相关性。
关键词:消化系统肿瘤； 正电子发射断层显像术； 病理学； 分子生物学
The association of FDG-PET/CT SUV with molecular biology in digestive canal cancer
OUYANG Lin，ZHOU Li-juan，SHI Zhao-yin，YANG Zan-jun，LIU Wei-hong，SHOU Yuan-miao.Image Department of 175 Hospital (Affiliated Hospital of Xiamen University Medical College)，Zhangzhou 363000，China
Abstract:Objective To investigate the association of FDG uptake index of digestive canal cancer PET image with molecular biological behaviour.Methods Twenty-four patients with digestive canal cancer with complete PET/CT，surgical operation and pathology data were enrolled.Retrospectivly analyzed the correlation between FDG uptake index( SUV value) and cancer infiltration，and lymph node metastasis and Ki-67，p53，C-erbB-2 expression.Results The FDG uptake index SUV value of 24 subjects，the lowest was 2.5，the highest was 12，the average was 6.34±2.54，were divided equally into hypometabolism group and hypermetabolism group，hypometabolism group average SUV was 4.39±1.31，hypermetabolism group average SUV was 8.48±1.38，the discrepance of SUV average value between two groups had statistical significance(t＝2.418，P＜0.05)，the discrepance of cancer infiltrating depth had no statistical significance(χ2＝0，P＞0.05)，the discrepance of incidence of lymphaden metastasis had no statistical significance(χ2＝0.686，P＞0.05).The Ki-67 value of 24 subjects，the lowest was 20%，the highest was 65%，the average was (41±11)%.The associativity of SUV value and Ki-67 value had no statistical significance(r＝－0.22，P＞0.05).The Ki-67 value of hypometabolism and hypermetabolism were (43±13)% and (38±9)% respectively，the discrepance of two groups had no statistical significance(t＝0.225，P＞0.05).The discrepance of p53 positive cases of hypometabolism and hypermetabolism had no statistical significance(χ2＝0.711，P＞0.05).The discrepance of C-erbB-2 positive cases of hypometabolism and hypermetabolism had no statistical significance(χ2＝0.686，P＞0.05).Conclusions The SUV of digestive canal cancer PET image 18F-FDG standard uptake value had comparatively large variation，had no significant associativity with cancer infiltrating depth and neighbourhood lymphaden metastases，had no significant associativity with the expression of tumor multiplication factor Ki-67， oncogene p53 and C-erbB-2.
Key words:Digestive system neoplasms； Positron-emission tomography； Pathology；Molecular biology
文献标引:欧阳林，周丽娟，时昭胤，杨赞军，刘威宏，寿元苗.消化系统肿瘤FDG PET/CT显像标准摄取值与分子生物学的相关性[J/CD].中华临床医师杂志：电子版,2010,4(8):1232-1237.
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